Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences

Speaker
John S Pixley
Texas Tech University Health Science Center, USA, USA
Biography

John S Pixley joined the faculty at Texas Tech University Health Science Center as the J T and Margaret Talkington Endowed Chair and Division Chief in Rheumatology/Immunology in 2015. Previously, he was at the University of Nevada School of Medicine as Division Chief of Rheumatology. His research over the past 20 years has focused on developing in utero transplantation as a scientific method and its poorly recognized capability to further understanding of Immune ontogeny of self-tolerance and Human stem cell pluripotency in vivo in a tolerant environment.

Abstract

Abstract The discovery of common placental circulation between twins coupled with the development of erythrocyte profiling in cattle allowed Ray Owen (Science 1945) to determine that dizygotic twins were chimeric with their sibling’s blood cells after birth. Thus, he concluded that self-tolerance is acquired during fetal development by the intermingling of sibling cells via the placental circulation. Further, he concluded immune tolerance to self is not genetically determined or innate!! They have exploited this process to engraft human stem cells in a large animal (sheep) via in utero transplantation (IUT). Advantages to large animal investigation include long life span and large size to permit serial sampling. Using parallel serial studies in developing sheep fetuses stem cell engraftment receptivity and sheep lymphoid ontogeny were assayed longitutinally. Then they were able to identify an engraftment window and propose our antigen exposure model to explain acquisition of immune tolerance to self as chimeric animals display life-long immune tolerance to the graft. The subsequent chimeras yield human hematopoietic, islet, hepatic, cardiac and gastrointestinal cellular elements in situ. Circulating human proteins (IgM, Albumin, Factor VIII, C-peptide and ?-fetoprotein) are detected years after transplantation. Therefore, they believe a fully tolerant large animal host provides an ideal in vivo method to test human stem cell differentiation capacity. This presentation will discuss evidence for immune tolerance, the pivotal role of the thymus and potential advantages/controversies in assaying stem cell differentiation in vivo (in comparison to immune deficient animal models) following IUT. Limitations to stem cell differentiation following IUT will be discussed as well.

Speaker Presentations

Speaker Presentations

Speaker PDFs

Allied Academies Global Conference Directory

Mail us at

Program Enquiry
connect@conferencesmeet.com
Exhibitor | Sponsorship | Partnering
sponsor@alliedglobalevents.com
WhatsApp Queries
enquire@conferencesmeet.com
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions

Responsibility

The organizers hold no responsibilities or liabilities of the personal articles of attendees at the venue against any kind of theft, loss, damage, due to any reason whatsoever. Delegates are entirely responsible for the safety of their own belongings.

 

Insurance

No insurance, of any kind, is included along with the registration in any of the events of the organization.

 

Transportation

Please note that transportation and parking is the responsibility of the registrant, Allied Academies will not be liable for any actions howsoever related to transportation and parking.

 

Press/Media

Press permission must be obtained from Allied Academies Conference Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party nonprofit organization and this conference is not associated with any commercial meeting company.

 

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference after payment of complete registration fee. Once registration is complete, please contact womenhealthcongress@alliedmeeting.org to request a personalized letter of invitation, if not received until one month before the scheduled date of the event.

All the bank charges applicable during refund will be deducted from the account of participant.

 

Cancellation Policy

All cancellations or modifications of registration must be made in writing to finance@alliedacademies.com

If due to any reason, Allied academies postpone an event on the scheduled date, the participant is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within the period of one year from the date of rescheduling.

Postponement of event 

If due to any reason, Allied academies postpone an event and the participant is unable or unwilling to attend the conference on rescheduled dates, he/she is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within the period of one year from the date of rescheduling.

Transfer of registration

All registrations, after payment of complete registration fee, are transferable to other persons from the same organization, if in case the person is unable to attend the event. Request for transfer of registration must be made by the registered person in writing to finance@alliedacademies.com. Details must include the full name of replaced new registrant, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

This cancellation policy was last updated on April 04, 2015.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues are not covered under the cancellation policy of Allied academies, including the inability to obtain a visa.

 Refund Policy:

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund policies apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overhead charges, following Refund Policy Orders are available:

·   Before 60 days of the conference: Eligible for Full Refund after deduction of $100 towards service Fee.

·         Within 60-30 days of Conference: Eligible for 50% of payment Refund

·         Within 30 days of Conference: Not eligible for Refund

·         E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Service Providers (Hotels) have their own cancellation policies which are applicable when cancellations are made less than 30 days prior to arrival. If in case the registrant wishes to cancel or amend the accommodation, he/ she is expected to inform the organizing authorities on a prior basis. Allied academies will advise the registrant to ensure complete awareness of the cancellation policy of your accommodation provider, prior to cancellation or modification of their booking.

Authorization Policy

Copyright © 2020-2021 Allied Academies, All Rights Reserved.